Pure silica ITQ-32 zeolite allows separation of linear olefins from paraffins

[EN] ITQ-32 is able to separate propene from propane and represents a clear improvement with respect to previous zeolites in achieving the separation of trans-2-butene and 1-butene from the C(4) fraction using only one zeolite.Palomino Roca, M.; Cantin Sanz, A.; Corma Canós, A.; Leiva Herrero, S.; Rey Garcia, F.; Valencia Valencia, S. (2007). Pure silica ITQ-32 zeolite allows separation of linear olefins from paraffins. Chemical Communications. 12:1233-1235. doi:10.1039/b700358gS123312351

Different modulation of RPS6 phosphorylation by risperidone in striatal cells sub populations: involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms in mice

Objective: Acute extrapyramidal symptoms (EPS) are frequent and serious adverse reactions to antipsychotic (AP) drugs. Although the proposed mechanism is an excessive blockade of dopamine D2 receptors in the striatopallidal pathway of the striatum, previous studies implicated the mTOR pathway in the susceptibility to EPS. The objective of the present study is to analyze the mTOR-mediated response to risperidone in subpopulations of striatal neurons and its relationship to risperidone-induced motor side effects. Methods: Two mouse strains (A/J and DBA/2J) with different susceptibility to developing EPS were treated with risperidone 1 mg/kg for three consecutive days. Here we monitored, by double labeling immunohistochemistry, ribosomal protein S6 (rpS6) phosphorylation (Ser235/236 and Ser244/247 sites), a marker of mTOR signaling, in the striatonigral pathway (D1-medium spiny neurons (MSNs)), the striatopallidal pathway (D2-MSNs) and striatal cholinergic interneurons. Results: We found that EPS-resistant DBA/2J mice show higher baseline levels of phosphoactivated rpS6 protein in striatal MSNs, compared with EPS-prone A/J mice. Moreover, risperidone differentially targeted rpS6 phosphorylation in direct and indirect pathway neurons in a strain-specific manner: a significant decrease in the phosphorylation of rpS6 at Ser235/236 and Ser240/244 in DRD1-MSNs EPS-resistant DBA/2J mice after; and a significant increase of phospho-Ser235/236-rpS6 in the striatopallidal pathway of the EPS-prone A/J mice in response to risperidone. Conclusions: Our results reveal the vital role of genetic background in the response to risperidone, and point to the mTOR pathway as an important factor in EPS susceptibility. Keywords: Schizophrenia, Antipsychotic, Risperidone, Extrapyramidal symptoms. mTOR pathway, Striatum, Medium spiny neuron

Structural study of pure silica and Ge-containing zeolite ITQ-24

[EN] The possibility to obtain zeolite ITQ-24 in a wide Si/Ge range of compositions have made possible to study the preferential location of Ge atoms in the zeolitic framework. Also, it has allowed studying the effect of zeolite composition on the thermal properties of these materials, varying their composition while maintaining a neutral framework without extra-framework cations.J.L.J thanks the Spanish MEC for a Juan de la Cierva contract, and M.M. to CSIC for an I3P grant. Authors thank Dr. Alejandro Vidal-Moya and Estrella Mateos for NMR measurements. The authors thank the Spanish CICYT (MAT2003-07945- C02-01 and MAT2003-07769-C02-01) and Generalitat Valenciana (project GV04B-270) for financial support.Jorda Moret, JL.; Cantin Sanz, A.; Corma Canós, A.; Díaz Cabañas, MJ.; Leiva Herrero, S.; Moliner Marin, M.; Rey Garcia, F.... (2007). Structural study of pure silica and Ge-containing zeolite ITQ-24. Zeitschrift für Kristallographie. Suppl.26:393-398. http://hdl.handle.net/10251/101702S393398Suppl.2

Exploiting visual cues for safe and flexible cyber-physical production systems

Human workers are envisioned to work alongside robots and other intelligent factory modules, and fulfill supervision tasks in future smart factories. Technological developments, during the last few years, in the field of smart factory automation have introduced the concept of cyber-physical systems, which further expanded to cyber-physical production systems. In this context, the role of collaborative robots is significant and depends largely on the advanced capabilities of collision detection, impedance control, and learning new tasks based on artificial intelligence. The system components, collaborative robots, and humans need to communicate for collective decision-making. This requires processing of shared information keeping in consideration the available knowledge, reasoning, and flexible systems that are resilient to the real-time dynamic changes on the industry floor as well as within the communication and computer network infrastructure. This article presents an ontology-based approach to solve industrial scenarios for safety applications in cyber-physical production systems. A case study of an industrial scenario is presented to validate the approach in which visual cues are used to detect and react to dynamic changes in real time. Multiple scenarios are tested for simultaneous detection and prioritization to enhance the learning surface of the intelligent production system with the goal to automate safety-based decisions

The alpha-galactosidase A p.Arg118Cys variant does not cause a Fabry disease phenotype: data from individual patients and family studies

Lysosomal α-galactosidase A (α-Gal) is the enzyme deficient in Fabry disease (FD), an X-linked glycosphingolipidosis caused by pathogenic mutations affecting the GLA gene. The early-onset, multi-systemic FD classical phenotype is associated with absent or severe enzyme deficiency, as measured by in vitro assays, but patients with higher levels of residual α-Gal activity may have later-onset, more organ-restricted clinical presentations. A change in the codon 118 of the wild-type α-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue – GLA p.(Arg118Cys) –, has been recurrently described in large FD screening studies of high-risk patients. Although the Cys118 allele is associated with high residual α-Gal activity in vitro, it has been classified as a pathogenic mutation, mainly on the basis of theoretical arguments about the chemistry of the cysteine residue. However its pathogenicity has never been convincingly demonstrated by pathology criteria. We reviewed the clinical, biochemical and histopathology data obtained from 22 individuals of Portuguese and Spanish ancestry carrying the Cys118 allele, including 3 homozygous females. Cases were identified either on the differential diagnosis of possible FD manifestations and on case-finding studies (n=11; 4 males), or on unbiased cascade screening of probands’ close relatives (n=11; 3 males). Overall, those data strongly suggest that the GLA p.(Arg118Cys) variant does not segregate with FD clinical phenotypes in a Mendelian fashion, but might be a modulator of the multifactorial risk of cerebrovascular disease, since the allelic frequency in stroke patients was 0.0087 (p=0.0185 vs the general population). The Cys118 allelic frequency in healthy Portuguese adults (n=696) has been estimated as 0.001, therefore not qualifying for “rare” conditio

Guía de buenas prácticas para establecimientos lecheros : material de referencia de la Red de BPA

Con el objetivo de concentrar varios esfuerzos aislados que se han llevado a cabo en el país, INTA, la Fac. Cs. Agropecuarias de la UNC y APROCAL han tenido la iniciativa de convocar a especialistas y representantes del sector lechero nacional para trabajar en el desarrollo de una guía de buenas prácticas en el tambo consensuada entre los diferentes representantes del sector lechero. Esta guía procura ser una propuesta de fácil interpretación para ser consultada permanentemente por parte de quienes trabajan y conducen los establecimientos lecheros para apoyarse en aspectos que hacen al aseguramiento de la calidad en el tambo. A través de esta se pretende brindar recomendaciones de Buenas Prácticas para maximizar la producción y la calidad de leche en sistemas productivos sustentables.EEA PergaminoFIL: Negri Rodriguez, Livia María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Tecnología de Alimentos; Argentina. Asociación PRO Calidad de la Leche y sus Derivados (PROCAL); ArgentinaFil: Aimar, María Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina. Asociación PRO Calidad de la Leche y sus Derivados (PROCAL); ArgentinaFil: Costamagna, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Callieri, Carlos. DeLaval Productor de Maquinaria Lechera y Agrícola; Argentina. Asociación PRO Calidad de la Leche y sus Derivados (PROCAL); ArgentinaFil: Herrero, María Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Charlón, Verónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Leiva, Antonio. Sancor; ArgentinaFil: Tentor, Gonzalo. Buenas Prácticas Agropecuarias (BPA); ArgentinaFil: Raciti, Julio. Manfrey Informatica; ArgentinaFil: Rampone, Alberto. Universidad Nacional de Villa María; ArgentinaFil: Chavez, Javier. Lactodiagnóstico Sur; ArgentinaFil: Gaggiotti, Mónica del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Boffa, Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Paraná. Agencia de Extensión Rural La Paz. Oficina Técnica Hernandarias; ArgentinaFil: Mancuso, Walter. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Praraná; ArgentinaFil: Pautasso, Néstor. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Praraná; ArgentinaFil: Walter, Emilio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Moltoni, Luciana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Ingeniería Rural; ArgentinaFil: Serrano, Pedro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Coronel Brandsen; ArgentinaFil: Abdala, Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Gonzalez Pereyra, Ana Valeria. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Lactodiagnóstico Sur; ArgentinaFil: Sardi, Graciela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Gigli, Isabel. Universidad Nacional de La Pampa; ArgentinaFil: Rodríguez, Julián. La Lacteo; ArgentinaFil: García, Karina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Brunas, Lucas. García Hermanos; ArgentinaFil: Bontá, Marcos. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Lactodiagnóstico Sur; Argentin

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research